Search results
Results From The WOW.Com Content Network
Clostridium perfringens (formerly known as C. welchii, or Bacillus welchii) is a Gram-positive, bacillus (rod-shaped), anaerobic, spore-forming pathogenic bacterium of the genus Clostridium. [ 1 ] [ 2 ] C. perfringens is ever-present in nature and can be found as a normal component of decaying vegetation, marine sediment , the intestinal tract ...
The key Clostridium septicum virulence factor is a pore-forming toxin called alpha-toxin, though it is unrelated to the Clostridium perfringens alpha-toxin. Clostridium sordellii can also produce two major toxins: all known virulent strains produce the essential virulence factor lethal toxin (TcsL), and a number also produce haemorrhagic toxin ...
This toxin has been shown to be the key virulence factor in infection with C. perfringens; the bacterium is unable to cause disease without this toxin. [1] Further, vaccination against the alpha toxin toxoid protects mice against C. perfringens gas gangrene. [2]
Clostridium perfringens is an anaerobic, gram-positive bacteria that is often found in the large and small intestines of humans and other animals. Clostridium perfringens has the ability to reproduce quickly producing toxins relating to the cause of diseases.
Clostridium perfringens causes a wide range of symptoms, from food poisoning to cellulitis, fasciitis, necrotic enteritis and gas gangrene. [16] [17] Clostridium tetani causes tetanus. Several more pathogenic species, that were previously described in Clostridium, have been found to belong to other genera. [6]
Because C. perfringens beta toxin shares homology with S. aureus pore-forming alpha toxin, it was hypothesized that beta toxin acts in a similar way. Upon investigation, it was found that C. perfringens beta toxin forms cation-selective pores in cell membranes [4] of 1.6–1.8 nm [5] and results in swelling and lysis in HL60 cells. [6]
Enterotoxemia is a condition induced by the absorption of large volumes of toxins produced by bacteria such as Clostridium perfringens from the intestines. [1] There are several strains of C. perfringens (type B, C, and D) that may lead to the development of this gastrointestinal condition. [citation needed]
It can be produced by Clostridium perfringens, Staphylococcus aureus, Pseudomonas aeruginosa or Listeria monocytogenes. C. perfringens alpha toxin (lecithinase) causes myonecrosis and hemolysis. The lecithinase of S. aureus is used in detection of coagulase-positive strains, because of high link between lecithinase activity and coagulase activity.