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In bone, mineralization starts from a heterogeneous solution having calcium and phosphate ions. The mineral nucleates, inside the hole area of the collagen fibrils, as thin layers of calcium phosphate, which then grow to occupy the maximum space available there. The mechanisms of mineral deposition within the organic portion of the bone are ...
Bone is broken down by osteoclasts, and rebuilt by osteoblasts, both of which communicate through cytokine (TGF-β, IGF) signalling. Ossification (also called osteogenesis or bone mineralization) in bone remodeling is the process of laying down new bone material by cells named osteoblasts. It is synonymous with bone tissue formation. [1]
The matrix is hardened by the binding of inorganic mineral salt, calcium phosphate, in a chemical arrangement known as bone mineral, a form of calcium apatite. [8] [9] It is the mineralization that gives bones rigidity. Bone is actively constructed and remodeled throughout life by specialized bone cells known as osteoblasts and osteoclasts.
Mineralization may refer to: Biomineralization (mineralization in biology), when an inorganic substance precipitates in an organic matrix Mineralized tissues are tissues that have undergone mineralization, including bones, teeth, antlers, and marine shells Bone remodeling, involving demineralization and remineralization in bones
The bone salt and collagen fibers together constitute the extracellular matrix of bone tissue. Often the plural form "bone salts" is used; it reflects the notion of various salts that, on the level of molecular metabolism, can go into the formation of the hydroxyapatite. Bone mineral is dynamic in living animals; it is continually being ...
The stoichiometry of bone mineral basically is that of hydroxyapatite precipitating from phosphate, calcium, and water at a slightly alkaline pH: [29] 6 HPO 2− 4 + 2 H 2 O + 10 Ca 2+ ⇌ Ca 10 (PO 4) 6 (OH) 2 + 8 H + In a closed system as mineral precipitates, acid accumulates, rapidly lowering the pH and stopping further precipitation ...
Mineralized osseous tissue or bone tissue, is of two types – cortical and cancellous and gives it rigidity and a coral-like three-dimensional internal structure. Other types of tissue found in bones include marrow, endosteum, periosteum, nerves, blood vessels and cartilage. Bone is an active tissue composed of different cells.
In addition, it permits the vesicular transcytosis of the mineral and degraded collagen from the ruffled border to the free membrane of the cell, and its release into the extracellular compartment. [21] [22] This activity completes the bone resorption, and both the mineral components and collagen fragments are released to the general circulation.