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The human immunodeficiency virus (HIV) [8] [9] [10] is a retrovirus [11] that attacks the immune system.It is a preventable disease. [5] It can be managed with treatment and become a manageable chronic health condition. [5]
The management of HIV/AIDS typically involves the use of multiple antiretroviral drugs. In many parts of the world, HIV has become a chronic condition, with progression to AIDS increasingly rare. HIV latency and the resulting viral reservoir in CD4 + T cells, dendritic cells, and macrophages is the main barrier to eradication of the virus. [19 ...
A small proportion of humans show partial or apparently complete innate resistance to HIV, the virus that causes AIDS. [1] The main mechanism is a mutation of the gene encoding CCR5, which acts as a co-receptor for HIV. It is estimated that the proportion of people with some form of resistance to HIV is under 10%. [2]
However, this argument has been described as an example of the fallacy of a statistical confounding effect; [9] it is now known that a herpesvirus, potentiated by HIV, is responsible for AIDS-associated KS. [10] [11] Moreover, in addition to recreational drugs, Duesberg argues that anti-HIV drugs such as zidovudine (AZT) can cause AIDS ...
However, direct killing by HIV alone cannot account for the observed depletion of CD4 + T cells since only 0.01–0.10% of CD4 + T cells in the blood are infected. [ citation needed ] A major cause of CD4 + T cell loss appears to result from their heightened susceptibility to apoptosis when the immune system remains activated.
HIV/AIDS denialism is the belief, despite conclusive evidence to the contrary, that the human immunodeficiency virus (HIV) does not cause acquired immune deficiency syndrome (AIDS). [ 1 ] [ 2 ] [ 3 ] Some of its proponents reject the existence of HIV, while others accept that HIV exists but argue that it is a harmless passenger virus and not ...
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