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The most commonly used stain in histology is a combination of hematoxylin and eosin (often abbreviated H&E). Hematoxylin is used to stain nuclei blue, while eosin stains the cytoplasm and the extracellular connective tissue matrix of most cells pink. There are hundreds of various other techniques which have been used to selectively stain cells.
Histopathology is the branch of histology that includes the microscopic identification and study of diseased tissue. [ 5 ] [ 6 ] It is an important part of anatomical pathology and surgical pathology , as accurate diagnosis of cancer and other diseases often requires histopathological examination of tissue samples. [ 10 ]
The Alzheimer type II astrocyte is thought to be a pathological type of cell in the brain; however, its exact pathology remains unknown. Like other astrocytes, it is a non-neuronal glial cell. It's mainly seen in diseases that cause increased levels of ammonia (hyperammonemia), such as chronic liver disease and Wilson's disease. [1]
Molecular pathology is an emerging discipline within anatomical and clinical pathology that is focused on the use of nucleic acid-based techniques such as in-situ hybridization, reverse-transcriptase polymerase chain reaction, and nucleic acid microarrays for specialized studies of disease in tissues and cells. Molecular pathology shares some ...
Clinically, IHC is used in histopathology for the diagnosis of specific types of cancers based on molecular markers. [ citation needed ] In laboratory science, immunostaining can be used for a variety of applications based on investigating the presence or absence of a protein, its tissue distribution, its sub-cellular localisation, and of ...
According to the Journal of the History of the Neurosciences, Dr. Lewy became interested in studying more about the brain , because of the discovery that Alois Alzheimer made in 1906. The article mentions that the third reported case of Alzheimer's disease had histological structures that happened to be similar to Lewy body histology slides ...
Defining cerebral cytoarchitecture began with the advent of histology—the science of slicing and staining brain slices for examination. [2] It is credited to the Viennese psychiatrist Theodor Meynert (1833–1892), who in 1867 noticed regional variations in the histological structure of different parts of the gray matter in the cerebral hemispheres.
Neuropathologists usually work in a department of anatomic pathology, but work closely with the clinical disciplines of neurology, and neurosurgery, which often depend on neuropathology for a diagnosis. Neuropathology also relates to forensic pathology because brain disease or brain injury can be related to cause of death.