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It is also common to experience various sensations in the skin, from crawling or tingling sensations, tenderness of palms and the soles, and numbness of hands, arm, legs or feet. [10] Other skin reactions include skin rash, swelling and stinging sensation. [10] Suramin can also cause loss of appetite and irritability. [10]
Diflunisal is a salicylic acid derivative with analgesic and anti-inflammatory activity. [2] It was developed by Merck Sharp & Dohme in 1971, as MK647, after showing promise in a research project studying more potent chemical analogs of aspirin. [3]
Skin rash: The most prominent feature is a reddish-purple rash that appears on the lower legs, typically below the knees and above the ankles. The rash is often described as blotchy, mottled, or net-like (reticular in appearance). [6] [7] In some cases, the rash may extend to the dorsum of the feet. [8]