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Dimenhydrinate (then known as Compound 1694) was being tested as a potential treatment for hay fever and hives at Johns Hopkins Hospital in 1947 by allergists Dr. Leslie Gay and Dr. Paul Carliner. Among those who received the drug was a pregnant woman who had suffered from motion sickness her entire life.
Diphenhydramine tablets. Diphenhydramine is a first-generation antihistamine used to treat several conditions including allergic symptoms and itchiness, the common cold, insomnia, motion sickness, and extrapyramidal symptoms.
Dimenhydrinate (Gravol, Dramamine) Doxylamine (Bonjesta, Unisom) Mirtazapine (Remeron) is an antidepressant that also has antiemetic effects. [5] [6] It is a potent histamine H1 receptor antagonist, K i =1.6 nM, [7] and also exhibits notable 5-HT 3 antagonism. [6] Meclizine (Bonine, Antivert)
"Treatment of vertigo due to acute unilateral vestibular loss with a fixed combination of cinnarizine and dimenhydrinate: a double-blind, randomized, parallel-group clinical study". Clin Ther . 26 (6): 866– 77.
Second-generation H 1-antihistamines are newer drugs that are much more selective for peripheral H 1 receptors as opposed to the central nervous system H 1 receptors and cholinergic receptors. This selectivity significantly reduces the occurrence of adverse drug reactions, such as sedation, while still providing effective relief of allergic ...
Antihistamines are drugs which treat allergic rhinitis, common cold, influenza, and other allergies. [1] Typically, people take antihistamines as an inexpensive, generic (not patented) drug that can be bought without a prescription and provides relief from nasal congestion, sneezing, or hives caused by pollen, dust mites, or animal allergy with few side effects. [1]
I take motion sickness pills, not because I get motion sickness, but because I’ve found they really help me feel centered as I move through all of that. They keep me from getting woozy ...
8-Chlorotheophylline, also known as 1,3-dimethyl-8-chloroxanthine, is a stimulant drug of the xanthine chemical class, with physiological effects similar to caffeine. [1] Its main use is in combination (salt) with diphenhydramine in the antiemetic dimenhydrinate (Dramamine).