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The level of digoxin for treatment is typically 0.5-2 ng/mL. [8] Since this is a narrow therapeutic index, digoxin overdose can happen. A serum digoxin concentration of 0.5-0.9 ng/mL among those with heart failure is associated with reduced heart failure deaths and hospitalizations. [9]
Other oculotoxic effects of digoxin include generalized blurry vision, as well as seeing a "halo" around each point of light. The latter effect can also be seen in van Gogh's 1889 painting The Starry Night. Evidence of van Gogh's digoxin use is supported by multiple self-portraits that include the foxglove plant, from which digoxin is obtained ...
Digoxin increased the risk of death in women by 23%. There was no difference in the death rate for men in the study. [38] Digoxin is also used as a standard control substance to test for P-glycoprotein inhibition. [39] Digoxin appears to be a peripherally selective drug due to limited brain uptake caused by binding to P-glycoprotein. [40] [41]
Digoxin immune fab or digoxin ... will further reduce serum potassium levels and could precipitate dangerous ... AWP of DigiFab has continued to increase as much as ...
Drug examples General indications Common side effects Cautions Special populations Digoxin [8]. Digitalis [8]. Digitoxin [8]. Heart failure with reduced ejection fraction [9]. Atrial Fibrillation (abnormal heart rhythm) [9]
Even less safe are drugs such as digoxin, a cardiac glycoside; its therapeutic index is approximately 2:1. [12] Other examples of drugs with a narrow therapeutic range, which may require drug monitoring both to achieve therapeutic levels and to minimize toxicity, include dimercaprol, theophylline, warfarin and lithium carbonate.
Learn the sneaky signs of protein overconsumption and why too much of this essential nutrient can harm ... 6 Sneaky Signs You're Eating Too Much Protein—and Why Experts Say It Can Be Dangerous.
Name Other common names Scientific name Adverse effects Aconite: monkshood, wolfsbane, aconitum [4]: Aconitum spp. : Heart palpitations and arrhythmias, hypotension, nausea, vomiting, abdominal pain, respiratory system paralysis, death [4] [5]