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Historically, symptoms resembling FPIES were first reported in the 1960s, but awareness of the disease was limited for decades after. More recently, awareness has increased with establishment of an ICD-10 code in 2016, and the publication of the first international consensus guidelines for FPIES diagnosis by the American Academy of Allergy, Asthma, and Immunology in 2017.
Different underlying brain dysfunctions have been hypothesized to result in the common symptoms of autism, just as completely different brain types result in intellectual disability. [1] [5] In recent years, the prevalence and number of people diagnosed with the disorder have increased dramatically. There are many potential reasons for this ...
The autism spectrum may comprise a small set of disorders that converge on a few common molecular pathways, or it may be a large set of disorders with diverse mechanisms. [16] Autism appears to result from developmental factors that affect many or all functional brain systems. [17]
[9] [10] For adult diagnosis, clinicians identify neurodevelopmental history, behaviors, difficulties in communication, limited interests and problems in education, employment, and social relationships. Challenging behaviors may be assessed with functional analysis to identify the triggers causing them. [11]
A 2006 review questioned the common assumption that most children with autism have an intellectual disability. [51] It is possible that the association between an intellectual disability and autism is not because they usually have common causes, but because the presence of both makes it more likely that both will be diagnosed. [52]
Classic autism, also known as childhood autism, autistic disorder, or Kanner's syndrome, is a formerly diagnosed neurodevelopmental disorder first described by Leo Kanner in 1943. It is characterized by atypical and impaired development in social interaction and communication as well as restricted, repetitive behaviors, activities, and interests.