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PZ-601 is a carbapenem antibiotic currently being tested as having a broad spectrum of activity including strains resistant to other carbapenems. Despite early Phase II promise, Novartis (who acquired PZ-601 in a merger deal with Protez Pharmaceuticals) recently dropped PZ-601, citing a high rate of adverse events in testing.
Like all carbapenem antibiotics, ertapenem has a broader spectrum of activity than other beta-lactams like penicillins and cephalosporins. Similar to doripenem , meropenem and biapenem , ertapenem has slightly better activity against many Gram-negative bacteria than other carbapenems such as imipenem .
Thienamycin was the first among the naturally occurring class of carbapenem antibiotics to be discovered and isolated. [3] Carbapenems are similar in structure to their antibiotic “cousins” the penicillins. Like penicillins, carbapenems contain a β-lactam ring (cyclic amide) fused to a five-membered ring. Carbapenems differ in structure ...
Meropenem, sold under the brand name Merrem among others, is an intravenous carbapenem antibiotic used to treat a variety of bacterial infections. [3] Some of these include meningitis, intra-abdominal infection, pneumonia, sepsis, and anthrax.
One mechanism of resistance is mutation in or loss of outer membrane porins, preventing antibiotics from entering the cells. [21] Changes within the porin protein gene cause a frameshift, altering the porin structure and function. [21] Changes in the porin protein hinder the diffusion of carbapenem and other antibiotics into the periplasm. [22]
Tebipenem (brand name Orapenem) is a broad-spectrum orally-administered antibiotic, from the carbapenem subgroup of β-lactam antibiotics.It was developed as a replacement drug to combat bacteria that had acquired antibiotic resistance to commonly used antibiotics.
Pages in category "Carbapenem antibiotics" The following 18 pages are in this category, out of 18 total. This list may not reflect recent changes. ...
Rarely, the carbapenems can cause a clinically apparent acute cholestatic hepatitis that is usually self-limiting and not requiring therapy or intervention. In patients with vanishing bile duct syndrome, corticosteroids are often used but have not been shown to be beneficial and are best avoided.