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In immunology, clonal selection theory explains the functions of cells of the immune system (lymphocytes) in response to specific antigens invading the body. The concept was introduced by Australian doctor Frank Macfarlane Burnet in 1957, in an attempt to explain the great diversity of antibodies formed during initiation of the immune response .
[a] Clonal selection theory (CST): hematopoietic stem cells (1) differentiate and undergo genetic rearrangement to produce a population of cells possessing a wide range of pre-existing diversity with respect to antibody expression (2). Lymphocytes expressing antibodies that would lead to autoimmunity are filtered from the population (3), while ...
Clonal Selection Pseudo code on AISWeb; CLONALG in Matlab developed by Leandro de Castro and Fernando Von Zuben; Optimization Algorithm Toolkit in Java developed by Jason Brownlee which includes the following clonal selection algorithms: Adaptive Clonal Selection (ACS), Optimization Immune Algorithm (opt-IMMALG), Optimization Immune Algorithm (opt-IA), Clonal Selection Algorithm (CLONALG ...
Myriad receptors are produced through a process known as clonal selection. [ 2 ] [ 3 ] According to the clonal selection theory, at birth, an animal randomly generates a vast diversity of lymphocytes (each bearing a unique antigen receptor) from information encoded in a small family of genes.
He made significant contributions to the clonal selection theory. [2] Career. Talmage was born to American Presbyterian missionaries in Japanese-controlled Korea.
In the late 1950s however, the works of three scientists—Jerne, Talmage and Burnet (who largely modified the theory)—gave rise to the clonal selection theory, which proved all the elements of Ehrlich's hypothesis except that the specific receptors that could neutralize the agent were soluble and not membrane-bound. [17] [30]
It also describes “inadequately clothed” as “see-through clothing, not adequately covered, exposed breasts, buttocks or other private parts.” ...
Evolutionary art uses variation and selection to produce works of art; Evolutionary music does the same for works of music; Clonal selection theory sees the creation of adapted antibodies in the immune system as a process of variation and selection; Neural Darwinism proposes that neurons and their synapses are selectively pruned during brain ...