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Positive ANA as well as anti-DNA antibodies have been reported in patients with autoimmune thyroid disease. [ 65 ] [ 66 ] ANA can have a positive test result in up to 45% of people with autoimmune thyroid conditions or rheumatoid arthritis and up to 15% of people with HIV or hepatitis C .
Anti-double stranded DNA (Anti-dsDNA) antibodies are a group of anti-nuclear antibodies (ANA) the target antigen of which is double stranded DNA. Blood tests such as enzyme-linked immunosorbent assay (ELISA) and immunofluorescence are routinely performed to detect anti-dsDNA antibodies in diagnostic laboratories.
An extractable nuclear antigen panel, or an ENA panel, tests for presence of autoantibodies in the blood that react with proteins in the cell nucleus. It is usually done as a follow-up to a positive antinuclear antibody ( ANA ) test and when one is showing symptoms of an autoimmune disorder .
619289 Ensembl ENSG00000196460 ENSMUSG00000057173 UniProt Q6ZV50 D3YU81 RefSeq (mRNA) NM_001145664 NM_207403 NM_001367508 NM_001367509 NM_001367510 NM_001145660 RefSeq (protein) NP_001139136 NP_001354437 NP_001354438 NP_001354439 NP_001139132 Location (UCSC) Chr 2: 101.4 – 101.48 Mb Chr 1: 39.7 – 39.76 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse RFX family member 8, lacking ...
The lack of RFX binding activity in complementation group C results from mutations in the RFX5 gene encoding the 75-kD subunit of RFX (Steimle et al., 1995). RFX5 is the fifth member of the growing family of DNA-binding proteins sharing a novel and highly characteristic DNA-binding domain called the RFX motif.
The RFX1 gene is a member of the regulatory factor X (RFX) gene family, which encodes transcription factors that contain five conserved domains including a highly conserved, centrally located, winged helix DNA binding domain as well as a dimerization domain located in the C-terminal region of the sequence. [8]
Immunofluorescence staining pattern of anti-centromere antibodies on HEp-20-10 cells. Anti-centromere antibodies (ACAs; often styled solid, anticentromere) are autoantibodies specific to centromere and kinetochore function.
DNA-binding protein RFX2 is a protein that in humans is encoded by the RFX2 gene. [5] [6] This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X3, X4 ...