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3351 15551 Ensembl ENSG00000135312 ENSMUSG00000049511 UniProt P28222 P28334 RefSeq (mRNA) NM_000863 NM_010482 RefSeq (protein) NP_000854 NP_034612 Location (UCSC) Chr 6: 77.46 – 77.46 Mb Chr 9: 81.51 – 81.52 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse 5-hydroxytryptamine receptor 1B also known as the 5-HT 1B receptor is a protein that in humans is encoded by the HTR1B gene ...
The 5-HT 1 subfamily consists of five G protein-coupled receptors (GPCRs) that share 40% to 63% overall sequence homology, including 5-HT 1A, 5-HT 1B, 5-HT 1D, 5-HT 1E, and 5-HT 1F. [2] Receptors of the 5-HT 1 type, specifically, the 5-HT 1A and 5-HT 1D receptor subtypes, are present on the cell bodies. Receptors of the 5-HT1 type, specifically ...
The 5-HT 1B receptor as an example of a metabotropic serotonin receptor. Its crystallographic structure in ribbon representation. 5-HT receptors, 5-hydroxytryptamine receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in the central and peripheral nervous systems.
References range may vary with age, sex, race, pregnancy, [10] diet, use of prescribed or herbal drugs and stress. Reference ranges often depend on the analytical method used, for reasons such as inaccuracy, lack of standardisation, lack of certified reference material and differing antibody reactivity. [11]
15550 Ensembl ENSG00000178394 ENSMUSG00000021721 UniProt P08908 Q64264 RefSeq (mRNA) NM_000524 NM_008308 RefSeq (protein) NP_000515 NP_032334 Location (UCSC) Chr 5: 63.96 – 63.96 Mb Chr 13: 105.58 – 105.58 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse The serotonin 1A receptor (or 5-HT 1A receptor) is a subtype of serotonin receptors, or 5-HT receptors, that binds serotonin ...
It acts as an antagonist at the β-adrenergic, 5-HT 1A, and 5-HT 1B receptors. [1] [2] It has about five times the potency for the 5-HT 1B receptor (21 nmol/L) over the 5-HT 1A receptor (112 nmol/L). [3] It has anxiolytic effects in rodents. [4]
The drug is a silent antagonist of the serotonin 5-HT 1B receptor, unlike the related agent GR-127935. [ 1 ] [ 4 ] GR-55562 has around 10-fold selectivity for the serotonin 5-HT 1B receptor over the serotonin 5-HT 1D receptor and has only weak affinity for a number of other serotonin receptors .
5-(Nonyloxy)tryptamine (5-NOT) is a tryptamine derivative which acts as a selective agonist at the 5-HT 1B receptor.Increasing the O-alkoxy chain length in this series gives generally increasing potency and selectivity for 5-HT 1B, with highest activity found for the nonyloxy derivative, having a 5-HT 1B binding affinity of 1.0 nM, and around 300-fold selectivity over the related 5-HT 1A receptor.