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Extramammary Paget's disease (EMPD) is a rare and slow-growing cancer, which occurs within the epithelial tissues [1] and accounts for 6.5% of all Paget's disease. [2] This disease presents similarly to the more conventional form of mammary Paget's disease (MPD). [ 3 ]
Paget's disease of the breast (also known as mammary Paget's disease) is a rare skin change at the nipple nearly always associated with underlying breast cancer. [2] Paget's disease of the breast was first described by Sir James Paget in 1874. [3] The condition is an uncommon disease accounting for 1 to 4% of all breast cancers cases.
The highest levels of acid phosphatase are found in metastasized prostate cancer. Diseases of the bone, such as Paget's disease or hyperparathyroidism, diseases of blood cells, such as sickle-cell disease or multiple myeloma or lysosomal storage diseases, such as Gaucher's disease, will show moderately increased levels.
Stage 0 which is in situ disease or Paget's disease of the nipple. Stage 0 is a pre-cancerous or marker condition, either ductal carcinoma in situ (DCIS) or lobular carcinoma in situ (LCIS). Stages 1–3 are within the breast or regional lymph nodes. Stage 4 is a metastatic cancer. Metastatic breast cancer has a less favorable prognosis.
The first clinical manifestation of Paget's disease is usually an elevated alkaline phosphatase in the blood. [7] Paget's disease of right pelvic bone. Man of 80 years age. Paget's disease may be diagnosed using one or more of the following tests: Pagetic bone has a characteristic appearance on X-rays. A skeletal survey is therefore indicated.
Squamous cell carcinoma, melanoma in situ, Pagetoid Bowen's disease, ocular sebaceous carcinoma, and other carcinomas can all display pagetoid growth. The term pagetoid (i.e., 'Paget-like') is derived from the extramammary Paget's disease, wherein the large tumour cells are arranged singly or in small clusters within the epidermis and its ...
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