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A paradoxical reaction (or paradoxical effect) is an effect of a chemical substance, such as a medical drug, that is opposite to what would usually be expected. An example of a paradoxical reaction is pain caused by a pain relief medication .
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Paradoxical disinhibition is a paradoxical reaction, an uncommon but recognized phenomenon, characterized by acute excitement and an altered mental state, caused by benzodiazepines. The mechanism is poorly known, but the most accepted theory is that it occurs secondary to inhibition of the restraining influences of the cortex and frontal lobe ...
Although statements can be self referential without being paradoxical ("This statement is written in English" is a true and non-paradoxical self-referential statement), self-reference is a common element of paradoxes. One example occurs in the liar paradox, which is commonly formulated as the self-referential statement "This statement is false ...
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Malcolm Lader at the Institute of Psychiatry in London estimates the incidence of these adverse reactions at about 5%, even in short-term use of the drugs. [23] The paradoxical reactions may consist of depression, with or without suicidal tendencies, phobias, aggressiveness, violent behavior and symptoms sometimes misdiagnosed as psychosis.
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The name originates from the illustration in the paper by Daniel Gilbert et al. [1] that introduced the paradox. They consider a commuter who has the habit of walking to destinations within a mile of their origin, and biking to more distant destinations.