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2. Polyclonal antibodies - Wikipedia

   en.wikipedia.org/wiki/Polyclonal_antibodies

   Polyclonal antibodies (pAbs) are antibodies that are secreted by different B cell lineages within the body (whereas monoclonal antibodies come from a single cell lineage). They are a collection of immunoglobulin molecules that react against a specific antigen , each identifying a different epitope .

3. Monoclonal antibody - Wikipedia

   en.wikipedia.org/wiki/Monoclonal_antibody

   A monoclonal antibody ... polyclonal antibodies bind to multiple epitopes and are usually made by several different ... A difference in pI of at least 1 is necessary ...

4. Clone (cell biology) - Wikipedia

   en.wikipedia.org/wiki/Clone_(cell_biology)

   Clonality implies the state of a cell or a substance being derived from one source or the other. Thus there are terms like polyclonal—derived from many clones; oligoclonal [2] —derived from a few clones; and monoclonal—derived from one clone. These terms are most commonly used in context of antibodies or immunocytes.

5. Hybridoma technology - Wikipedia

   en.wikipedia.org/wiki/Hybridoma_technology

   In contrast to polyclonal antibodies, which are mixtures of many different antibody molecules, the monoclonal antibodies produced by each hybridoma line are all chemically identical. The production of monoclonal antibodies was invented by César Milstein and Georges J. F. Köhler in 1975.

6. Monoclonality - Wikipedia

   en.wikipedia.org/wiki/Monoclonality

   Monoclonal antibody: a single hybridoma cell, which by chance includes the appropriate V(D)J recombination to produce the desired antibody, is cloned to produce a large population of identical cells. In informal laboratory jargon, the monoclonal antibodies isolated from cell culture supernatants of these hybridoma clones (hybridoma lines) are ...

7. Anti-immunoglobulin - Wikipedia

   en.wikipedia.org/wiki/Anti-immunoglobulin

   Clonal antibodies can either be monoclonal or polyclonal. Monoclonal antibodies are clones of one antibody; therefore, monoclonal antibodies can only bind to one target. Polyclonal antibodies are clones of multiple antibodies and immune cells, so they can bind to various targets. [4] Recombinant clonal antibodies are produced through in-vitro ...