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  2. Pineal gland - Wikipedia

    en.wikipedia.org/wiki/Pineal_gland

    The pineal gland (also known as the pineal body [1] or epiphysis cerebri) is a small endocrine gland in the brain of most vertebrates. It produces melatonin, a serotonin-derived hormone, which modulates sleep patterns following the diurnal cycles. [2] The shape of the gland resembles a pine cone, which gives it its name. [3]

  3. Melatonin - Wikipedia

    en.wikipedia.org/wiki/Melatonin

    In vertebrates, melatonin is produced in darkness, thus usually at night, by the pineal gland, a small endocrine gland [72] located in the center of the brain but outside the blood–brain barrier. Light/dark information reaches the suprachiasmatic nuclei from retinal photosensitive ganglion cells of the eyes [ 73 ] [ 74 ] rather than the ...

  4. Pinealocyte - Wikipedia

    en.wikipedia.org/wiki/Pinealocyte

    An abundance of cilia and centrioles has also been found in these Type 2 cells of the pineal gland. [7] Unique to the Type 2 is the presence of vacuoles containing 2 layers of membrane. [7] As Type 1 cells contain serotonin, Type 2 cells contain melatonin and are thought to have similar characteristics as endocrine and neuronal cells. [8]

  5. Endocrine system - Wikipedia

    en.wikipedia.org/wiki/Endocrine_system

    The thyroid secretes thyroxine, the pituitary secretes growth hormone, the pineal secretes melatonin, the testis secretes testosterone, and the ovaries secrete estrogen and progesterone. [2] Glands that signal each other in sequence are often referred to as an axis, such as the hypothalamic–pituitary–adrenal axis.

  6. Endocrine gland - Wikipedia

    en.wikipedia.org/wiki/Endocrine_gland

    Endocrine glands are ductless glands of the endocrine system that secrete their products, hormones, directly into the blood. The major glands of the endocrine system include the pineal gland , pituitary gland , pancreas , ovaries , testicles , thyroid gland , parathyroid gland , hypothalamus and adrenal glands .

  7. Blood–brain barrier - Wikipedia

    en.wikipedia.org/wiki/Blood–brain_barrier

    Some examples of this include the circumventricular organs, the roof of the third and fourth ventricles, capillaries in the pineal gland on the roof of the diencephalon and the pineal gland. The pineal gland secretes the hormone melatonin "directly into the systemic circulation", [12] thus melatonin is not affected by the blood–brain barrier ...

  8. Epithalamus - Wikipedia

    en.wikipedia.org/wiki/Epithalamus

    The epithalamus is associated with sleep disorders like insomnia revolving around circadian rhythms of sleep wake cycles. The close connection of the epithalamus with the limbic system regulates the secretion of melatonin by the pineal gland and the regulation of motor pathways and emotions. [9] The secretion of melatonin happens in a cycle.

  9. Melatonin receptor 1A - Wikipedia

    en.wikipedia.org/wiki/Melatonin_receptor_1A

    This gene encodes the MT 1 protein, one of two high-affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland.This receptor is a G protein-coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length.