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Cyproterone acetate (CPA), sold alone under the brand name Androcur or with ethinylestradiol under the brand names Diane or Diane-35 among others, is an antiandrogen and progestin medication used in the treatment of androgen-dependent conditions such as acne, excessive body hair growth, early puberty, and prostate cancer, as a component of feminizing hormone therapy for transgender individuals ...
The volume of distribution of finasteride is 76 L. [5] Its plasma protein binding is 90%. [5] The drug has been found to cross the blood–brain barrier, whereas levels in semen were found to be undetectable. [5] Finasteride is extensively metabolized in the liver, first by hydroxylation via CYP3A4 and then by aldehyde dehydrogenase. [5]
The side effects of cyproterone acetate (CPA), a steroidal antiandrogen and progestin, including its frequent and rare side effects, have been studied and characterized.It is generally well-tolerated and has a mild side-effect profile, regardless of dosage, when it used as a progestin or antiandrogen in combination with an estrogen such as ethinylestradiol or estradiol valerate in women.
[177] [178] Retinoids contraindicated for use during pregnancy include the topical retinoid tazarotene, and oral retinoids isotretinoin and acitretin (all category X). [176] Spironolactone is relatively contraindicated for use during pregnancy due to its antiandrogen effects. [1] Finasteride is not recommended as it is highly teratogenic. [1]
Let’s talk 5mg finasteride vs 1mg—two different doses, one powerful hair loss treatment. Finasteride is the active ingredient in Propecia®, an oral medication that’s clinically-proven to ...
Contraindicated in pregnancy: Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use of the drug in pregnant women clearly outweigh potential benefits.
EE/CPA is used as a combined birth control pill to prevent ovulation and pregnancy in women. [2] It is also approved and used to treat androgen-dependent conditions in women such as acne , seborrhea , hirsutism , female pattern hair loss , and hyperandrogenism due to polycystic ovary syndrome .
Dutasteride is also used in the treatment of male pattern hair loss and appears to have better effectiveness than finasteride for the condition. [ 27 ] [ 28 ] [ 29 ] While used off-label for male pattern hair loss in most of the world, dutasteride is specifically approved for this indication in South Korea and Japan .