Search results
Results From The WOW.Com Content Network
Pyruvate oxidation is the step that connects glycolysis and the Krebs cycle. [4] In glycolysis, a single glucose molecule (6 carbons) is split into 2 pyruvates (3 carbons each). Because of this, the link reaction occurs twice for each glucose molecule to produce a total of 2 acetyl-CoA molecules, which can then enter the Krebs cycle.
The liver in mammals gets rid of this excess lactate by transforming it back into pyruvate under aerobic conditions; see Cori cycle. Fermentation of pyruvate to lactate is sometimes also called "anaerobic glycolysis", however, glycolysis ends with the production of pyruvate regardless of the presence or absence of oxygen.
Pyruvate, the conjugate base, CH 3 COCOO −, is an intermediate in several metabolic pathways throughout the cell. Pyruvic acid can be made from glucose through glycolysis , converted back to carbohydrates (such as glucose) via gluconeogenesis , or converted to fatty acids through a reaction with acetyl-CoA . [ 3 ]
Aerobic respiration requires oxygen (O 2) in order to create ATP.Although carbohydrates, fats and proteins are consumed as reactants, aerobic respiration is the preferred method of pyruvate production in glycolysis, and requires pyruvate be transported the mitochondria in order to be oxidized by the citric acid cycle.
Pyruvate, the product of glycolysis under aerobic conditions, is a metabolic branch point. As a preliminary to following the central path of aerobic metabolism from glycolysis to the citric acid cycle , we put pyruvate in perspective by considering its various possible fates.
Pyruvate dehydrogenase complex. Pyruvate dehydrogenase complex (PDC) is a complex of three enzymes that converts pyruvate into acetyl-CoA by a process called pyruvate decarboxylation. [1] Acetyl-CoA may then be used in the citric acid cycle to carry out cellular respiration, and this complex links the glycolysis metabolic pathway to the citric ...
Pyruvate dehydrogenase is an enzyme that catalyzes the reaction of pyruvate ... This enzyme increases the efficiency of growth of E. coli under aerobic conditions. [9 ...
Under aerobic conditions, the pyruvate is transported from the cytosol to the mitochondrion, where further energy can be extracted through the citric acid cycle (CAC) [citation needed] The liver can also create glucose ( gluconeogenesis , see below); during times of low carbohydrate supply from the digestive system, the liver creates glucose ...