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Multivitamins nutrition facts label showing that the international unit of, for example, vitamins D and E correspond to different gram values. In pharmacology, the international unit (IU) is a unit of measurement for the effect or biological activity of a substance, for the purpose of easier comparison across similar forms of substances.
The enzyme unit, or international unit for enzyme (symbol U, sometimes also IU) is a unit of enzyme's catalytic activity. [ 1 ] 1 U (μmol/min) is defined as the amount of the enzyme that catalyzes the conversion of one micro mole of substrate per minute under the specified conditions of the assay method .
At a typical intake of cholecalciferol (up to 2000 IU/day), conversion to calcifediol is rapid. When large doses are given (100,000 IU), it takes 7 days to reach peak calcifediol concentrations. [9] Calcifediol binds in the blood to vitamin D-binding protein (also known as gc-globulin) and is the main circulating vitamin D metabolite.
Food and supplement labels still generally use IU, but IU can be converted to the more useful retinol activity equivalent as follows: [19] 1 μg RAE = 3.33 IU retinol; 1 IU retinol = 0.3 μg RAE; 1 IU β-carotene from supplements = 0.3 μg RAE; 1 IU β-carotene from food = 0.05 μg RAE; 1 IU α-carotene or β-cryptoxanthin from food = 0.025 μg ...
The Swedish National Food Agency recommends a daily intake of 10 μg (400 IU) of vitamin D 3 for children and adults up to 75 years, and 20 μg (800 IU) for adults 75 and older. [175] Non-government organisations in Europe have made their own recommendations. The German Society for Nutrition recommends 20 μg. [176]
See Weight for detail of mass/weight distinction and conversion. Avoirdupois is a system of mass based on a pound of 16 ounces, while Troy weight is the system of mass where 12 troy ounces equals one troy pound.