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Class III antiarrhythmic drugs are potassium channel blockers that cause QT prolongation and are associated with TdP. Amiodarone. Amiodarone works in many ways. It blocks sodium, potassium, and calcium channels, as well as alpha and beta adrenergic receptors. Because of its multiple actions, amiodarone causes QT prolongation but TdP is rarely ...
Electrocardiogram (ECG) abnormalities are frequent and a wide variety of cardiac dysrhythmias can occur, the most common being sinus tachycardia and intraventricular conduction delay resulting in prolongation of the QRS complex and the PR/QT intervals. [4] Seizures, cardiac dysrhythmias, and apnea are the most important life-threatening ...
Any abnormality of conduction takes longer and causes "widened" QRS complexes. In bundle branch block, there can be an abnormal second upward deflection within the QRS complex. In this case, such a second upward deflection is referred to as R′ (pronounced "R prime"). This would be described as an RSR′ pattern.
Potassium channel blockers exhibit reverse use-dependent prolongation of the action potential duration. Reverse use dependence is the effect where the efficacy of the drug is reduced after repeated use of the tissue. [11] This contrasts with (ordinary) use dependence, where the efficacy of the drug is increased after repeated use of the tissue.
Antiarrhythmic agents, also known as cardiac dysrhythmia medications, are a class of drugs that are used to suppress abnormally fast rhythms (tachycardias), such as atrial fibrillation, supraventricular tachycardia and ventricular tachycardia.
Causes: Accessory pathway in the heart [1] Diagnostic method: Electrocardiogram shows a short PR interval and a wide QRS complex from a delta wave [3] Treatment: Watchful waiting, medications, radiofrequency catheter ablation [4] [5] Prognosis: Without symptoms 0.5% (children), 0.1% (adults) risk of death per year [5] Frequency: 0.2% [1]
The drug causes increased action potential duration, ... Quinidine can cause thrombocytopenia, ... Other ECG effects include a wide notched P wave, wide QRS complex ...
The QRS complexes represent an escape rhythm arising from the ventricle. Atrial tachycardia with complete A-V block and resulting junctional escape. Many conditions can cause third-degree heart block, but the most common cause is coronary ischemia. Progressive degeneration of the electrical conduction system of the heart can lead to third ...