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A recent large-scale study found that severe depression in patients with bipolar disorder responds no better to a combination of antidepressant medications and mood stabilizers than it does to mood stabilizers alone and that antidepressant use does not hasten the emergence of manic symptoms in patients with bipolar disorder.
Second-generation antipsychotics, including risperidone, are effective in the treatment of manic symptoms in acute manic or mixed exacerbations of bipolar disorder. [ 25 ] [ 26 ] [ 27 ] In children and adolescents, risperidone may be more effective than lithium or valproate , but has more metabolic side effects. [ 28 ]
Antipsychotic medications are effective for short-term treatment of bipolar manic episodes and appear to be superior to lithium and anticonvulsants for this purpose. [68] Atypical antipsychotics are also indicated for bipolar depression refractory to treatment with mood stabilizers. [ 120 ]
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Amisulpride, sold under the brand names Solian and Barhemsys, is a medication used in the treatment of schizophrenia, acute psychotic episodes, depression, and nausea and vomiting. [ 9 ] [ 6 ] It is specifically used at lower doses intravenously to prevent and treat postoperative nausea and vomiting ; [ 9 ] at low doses by mouth to treat ...
Olanzapine, sold under the brand name Zyprexa among others, is an atypical antipsychotic primarily used to treat schizophrenia and bipolar disorder. [13] It is also sometimes used off-label for treatment of chemotherapy-induced nausea and vomiting [14] and as an appetite stimulant. [15]
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