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Glucosamine and chondroitin are two compounds that occur naturally in your cartilage. Available in supplement form, they’re commonly taken together to lessen osteoarthritis pain and manage...
Although studies on glucosamine and chondroitin have been mixed, some evidence suggests they may help relieve OA joint pain and stiffness. What Are Glucosamine and Chondroitin? Glucosamine and chondroitin are natural compounds found in healthy cartilage — the connective tissue that cushions joints.
The 2019 ACR/AF guideline strongly recommends against the use of chondroitin alone or in combination with glucosamine for knee osteoarthritis, and the 2019 OARSI guideline strongly recommends against the use of chondroitin for knee osteoarthritis on the grounds that the evidence is of low quality.
A 2022 analysis of eight studies that included nearly 4,000 people with knee osteoarthritis found no convincing evidence that glucosamine and chondroitin provided major benefit. The case for these supplements protecting joint health or preventing arthritis from worsening is similarly weak.
Oral use of glucosamine sulfate might provide some pain relief for people with osteoarthritis of the knee. Some research shows that it may also help slow knee joint degeneration associated with osteoarthritis.
The effects of glucosamine use have been shown to be effective in the short-term. However, since osteoarthritis is a chronic disease, patients with osteoarthritis will take medication for most of their lives if no alternative therapy is available.
To assess the symptomatic effectiveness and safety of oral symptomatic slow-acting drugs (SYSADOAs) on the treatment of knee and/or hip osteoarthritis, such as chondroitin, glucosamine, and combination treatment with chondroitin plus glucosamine.
Joint and bone health: A 2016 study found glucosamine, taken with chondroitin, may offer benefits in treating osteoarthritis (OA), especially in the knee. Studies across two decades found mixed results on glucosamine benefits, but a 2023 review of 15 studies found glucosamine did relieve pain in people with knee osteoarthritis and short-term ...
Glucosamine chondroitin supplements may help with osteoarthritis pain, but the evidence for their effectiveness is still controversial. It can be risky to take supplements because they are not regulated by the FDA and you can't always be sure of how much of the active ingredients are in a product.
Together, glucosamine and chondroitin may reduce osteoarthritis pain, improve functioning, and reduce joint swelling and stiffness. Research shows the relief lasts for up to three months after stopping the supplements.