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Cerebral blood flow (CBF) is the blood supply to the brain in a given period of time. [8] In an adult, CBF is typically 750 millilitres per minute or 15.8 ± 5.7% of the cardiac output. [9] This equates to an average perfusion of 50 to 54 millilitres of blood per 100 grams of brain tissue per minute. [10] [11] [12]
The cerebral blood volume value of gray matter is about 3.5 +/- 0.4 ml/100g, and the white matter is about 1.7 +/- 0.4 ml/100g. The gray matter is nearly twice that of white matter. [3] In both white and gray matter, cerebral blood volume decreases by about 0.50% per year with increasing age. [4]
Brain ischemia has been linked to a variety of diseases or abnormalities. Individuals with sickle cell anemia, compressed blood vessels, ventricular tachycardia, plaque buildup in the arteries, blood clots, extremely low blood pressure as a result of heart attack, and congenital heart defects have a higher predisposition to brain ischemia in comparison to the average population.
The brain produces roughly 500 mL of cerebrospinal fluid per day at a rate of about 20 mL an hour. [18] This transcellular fluid is constantly reabsorbed, so that only 125–150 mL is present at any one time. [1] CSF volume is higher on a mL per kg body weight basis in children compared to adults.
Cerebral perfusion pressure, or CPP, is the net pressure gradient causing cerebral blood flow to the brain (brain perfusion).It must be maintained within narrow limits because too little pressure could cause brain tissue to become ischemic (having inadequate blood flow), and too much could raise intracranial pressure (ICP).
A procedure to place an external ventricular drain may be used to treat hydrocephalus or increased intracranial pressure, however, the use of corticosteroids is frequently avoided. [1] Sometimes surgery to directly remove the blood can be therapeutic. [1] Cerebral bleeding affects about 2.5 per 10,000 people each year. [2]
Heather Baynard, a 14-year-old with cerebral palsy, reportedly died on April 11, 2022, hours after her father carried her cold, gray, listless body into a local hospital like a sack of potatoes.
Overall, the relative incidence of neonatal encephalopathy is estimated to be between 2 and 9 per 1000 term births. [6] 40% to 60% of affected infants die by 2 years old or have severe disabilities. [15] In 2013 it was estimated to have resulted in 644,000 deaths down from 874,000 deaths in 1990. [20]