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An early example of a double-blind protocol was the Nuremberg salt test of 1835 performed by Friedrich Wilhelm von Hoven, Nuremberg's highest-ranking public health official, [5] as well as a close friend of Friedrich Schiller. [6] This trial contested the effectiveness of homeopathic dilution. [5]
In a double-blind experiment, half of the students received psilocybin, while a control group received a large dose of niacin. Niacin produces clear physiological changes and thus was used as an active placebo. In at least some cases, those who received the niacin initially believed they had received the psychoactive drug.
He was the first to use a double-blind procedure in investigating physical and psychological effects of consumption of tea, coffee, alcohol and drugs. For a time he directed centres for psychological studies at two colleges, and he was made a Fellow of St John's College, Cambridge .
Another issue was the inability to conduct the experiment utilizing the blind double-blind procedure. An additional strong criticism of the experiments was that non-drug effects on the subjects were largely underestimated, and the effects of the LSD were possibly overestimated. [1]
Occasionally, the double blind, a more secure way to avoid bias from both the subjects and the testers, is implemented. In this case, both the subjects and the testers are unaware of which group subjects belong to. The double blind design can protect the experiment from the observer-expectancy effect.
Both patient and assistant later died of sepsis, and a spectator reportedly died of shock, resulting in the only known surgical procedure with a 300% mortality rate.
Double blind techniques may be employed to combat bias by causing the experimenter and subject to be ignorant of which condition data flows from. It might be thought that, due to the central limit theorem of statistics, collecting more independent measurements will improve the precision of estimates, thus decreasing bias. However, this assumes ...
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