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Vinegar test is a cervical cancer testing method that uses acetic acid, a major component of vinegar. It has been found to be useful as an effective and inexpensive screening test. It has the potential, say researchers from the University of Zimbabwe and Johns Hopkins University, to improve the chances of preventing cancer in developing world. [1]
These visible growths, however, are the result of non-carcinogenic HPV types. Five percent acetic acid (vinegar) is used to identify both warts and squamous intraepithelial neoplasia (SIL) lesions with limited success [citation needed] by causing abnormal tissue to appear white, but most doctors have found this technique helpful only in moist ...
DNA tests are available for diagnosis of high-risk HPV infections. Because genital warts are caused by low-risk HPV types, DNA tests cannot be used for diagnosis of genital warts or other low-risk HPV infections. [4] Some practitioners use an acetic acid solution to identify smaller warts ("subclinical lesions"), but this practice is ...
Acetic acid solution is applied to the surface of the cervix using cotton swabs to improve visualization of abnormal areas. [citation needed]. Areas of the cervix that turn white (acetowhiteness) after the application of acetic acid or have an abnormal vascular pattern are often considered for biopsy.
Acetic acid has been used medically since the time of Ancient Egypt. [8] [9] It is on the World Health Organization's List of Essential Medicines. [10] Acetic acid is more commonly used for external ear infections in the developing world than the developed. [11]
Virtually all cervical cancer cases (99%) are linked to genital human papillomavirus infection (HPV); [14] [5] [6] most who have had HPV infections, however, do not develop cervical cancer. [3] [15] HPV 16 and 18 strains are responsible for approximately 70% of cervical cancer cases globally and nearly 50% of high grade cervical pre-cancers.
Those that have a prolonged infection with a high-risk type (e.g. types 16, 18, 31, 45) are more likely to develop Cervical Intraepithelial Neoplasia, due to the effects that HPV has on DNA. [ 7 ] The screening process utilizes nucleic acid amplification testing to look for DNA or RNA of the virus present within cervical cells.
The cause of CIN is chronic infection of the cervix with HPV, especially infection with high-risk HPV types 16 or 18. It is thought that the high-risk HPV infections have the ability to inactivate tumor suppressor genes such as the p53 gene and the RB gene, thus allowing the infected cells to grow unchecked and accumulate successive mutations, eventually leading to cancer.