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Oral ketoconazole has been used clinically as a steroidogenesis inhibitor in men, women, and children at dosages of 200 to 1,200 mg/day. [47] [48] [49] Numerous small studies have investigated the effects of oral ketoconazole on hormone levels in humans. [50]
In July 2013, the European Medicines Agency's Committee on Medicinal Products for Human Use (CHMP) advised that oral medicines containing Ketoconazole should be suspended due to the high risk of hepatotoxicity outweighing its benefits. The advice does not affect topical ketoconazole products, and the oral use of the drug for Cushing's syndrome.
Here, we’ll talk about what ketoconazole actually is (fret not, you can still eat carbs), what the science says about ketoconazole and hair growth, plus any side effects of the ingredients and ...
Levoketoconazole is the levorotatory or (2S,4R) enantiomer of ketoconazole, [4] [5] [6] and it is an inhibitor of the enzymes CYP11B1 (11β-hydroxylase), ...
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Miconazole is partly absorbed in the intestinal tract when used orally, as with the oral gel, and possibly when used vaginally. [9] This can lead to increased concentrations of drugs that are metabolized by the liver enzymes CYP3A4 and CYP2C9, because miconazole inhibits these enzymes.
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I did my doctorate on resistance to ketoconazole and fluconazole - back when they were just experimental samples from Jannsen and Pfizer. Certainly ketoconazole seemed more toxic than fluconazole. When resistance arose to ketoconazole one could still apply a high enough dose to suppress fungal growth.