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Fel d 1 is a secretoglobin protein complex that, in cats, is encoded by the CH1 (chain 1/Fel d 1-A) and CH2 (chain 2/Fel d 1-B) genes. [2] [3] Among cats, Fel d 1 is produced largely in their saliva and by the sebaceous glands located in their skin. It is the primary allergen present on cats and kittens.
Fel d 1 is the most prominent cat allergen, accounting for 96% of human cat allergies. [4] The remaining cat allergens are Fel d 2–8, [5] with Fel d 4, a major urinary protein found in the saliva of cats, [6] occurring the most in humans among the other seven allergens. All cats produce Fel d 1, including hypoallergenic cats.
Many people believe that the breed produces less Fel d 1, the primary allergen present in cats. [58] In 1999, Indoor Biotechnologies tested the fur of four cats for Fel d 1; a mixed breed, two Siberians, and an Abyssinian. [59] The results showed the Siberian and Abyssinian cat fur as having lower Fel d 1 levels than the mixed breed cat. [59]
The post 8 Hypoallergenic Cats for People with Allergies appeared first on Reader's Digest. If you love cats but can’t stop sneezing when you’re around them, don’t despair! These breeds may ...
Fel d 1 was supposed to be put into two subfamilies: chain 1 in subfamily 4, and chain 2 in subfamily 5. [3] Although it is not mentioned in the 2011 update, InterPro matches suggest that CH1 is similar to 1B and CH2 is similar to 2B. [5] Extra computational research confirms the similarity, invalidating subfamilies 4 and 5 fully. [6]
The proteins that cause allergies (mainly Fel d 1 in cats and Can f 1 in dogs) are found not only in the animals' fur or hair but also in saliva, urine, mucus, and hair roots and in the dander sloughed from the animals' skin. Thus, the widespread idea that "hypoallergenic pets" are those that have less hair or shed less is a myth.