Search results
Results From The WOW.Com Content Network
In humans, the SRY gene is located on short (p) arm of the Y chromosome at position 11.2. Sex-determining region Y protein (SRY), or testis-determining factor (TDF), is a DNA-binding protein (also known as gene-regulatory protein/transcription factor) encoded by the SRY gene that is responsible for the initiation of male sex determination in therian mammals (placentals and marsupials). [5]
The human Y chromosome showing the SRY gene which codes for a protein regulating sexual differentiation. Sexual differentiation in humans is the process of development of sex differences in humans. It is defined as the development of phenotypic structures consequent to the action of hormones produced following gonadal determination. [1]
The SRY gene, normally found on the Y chromosome, plays an important role in sex determination by initiating testicular development. In about 80 percent of XX males, the SRY gene is present on one of the X chromosomes. [16] [25] The condition results from an abnormal exchange of genetic material between chromosomes (translocation).
There are other variations in which, during embryonic development, the WNT4 gene [7] is activated and/or the SRY gene is damaged leading to birth of an XY female (Swyer syndrome [7]). A Y chromosome may also be present but fail to result in the development of a male phenotype in individuals with androgen insensitivity syndrome , instead ...
XY complete gonadal dysgenesis, also known as Swyer syndrome, is a type of defect hypogonadism in a person whose karyotype is 46,XY. Though they typically have normal vulvas, [1] the person has underdeveloped gonads, fibrous tissue termed "streak gonads", and if left untreated, will not experience puberty.
For example, in mammals, the SRY gene on the Y chromosome initiates testis development, but subsequent male sexual differentiation heavily relies on androgens. [86] Sexual Dimorphism: The combined effects of CASI and hormones contribute to the development of sexually dimorphic traits. In some cases, CASI may dictate cellular predispositions ...
The Human Y Chromosome showing the SRY gene which codes for a protein regulating sexual differentiation. The early stages of human differentiation appear to be quite similar to the same biological processes in other mammals—and the interaction of genes, hormones and body structures is fairly well understood.
As individuals with 46,XX/46,XY partially express the SRY gene, the normal process by which an embryo normally develops a phenotypic male or phenotypic female may be significantly affected causing variation will affect in the gonads, the reproductive tract, and the genitals. [6]