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Hemolytic jaundice, also known as prehepatic jaundice, is a type of jaundice arising from hemolysis or excessive destruction of red blood cells, when the byproduct bilirubin is not excreted by the hepatic cells quickly enough. [1]
The total average daily production of bilirubin in humans is 4 mg/kg. 80% of which is derived from haemoglobin (Hb) produced by erythrocyte breakdown, with the remaining from heme proteins, like myoglobin and cytochrome, turnover. [5] Hb is broken down into globin and haem, which then undergoes a multi-step enzymatic degradation process. [4]
Pathophysiology of phenylketonuria, which is due to the absence of functional phenylalanine hydroxylase (classical subtype) or functional enzymes for the recycling of tetrahydrobiopterin (new variant subtype) utilized in the first step of the metabolic pathway.
The underlying pathophysiology of frostbite is a combination of freezing, vascular insufficiency (constriction and occlusion) and damage due to inflammatory mediators. As extremities cool, the ‘hunting response of Lewis’ (alternating vasoconstriction and vasodilation) occurs, ending with vasoconstriction.
[2] [4] If this is insufficient for treating vasovagal syncope, medications such as midodrine or fludrocortisone may be tried. [4] Occasionally, a cardiac pacemaker may be used as treatment. [2] Reflex syncope affects at least 1 in 1,000 people per year. [1] It is the most common type of syncope, making up more than 50% of all cases. [2]
By Jonathan Stempel (Reuters) -Google failed to persuade a federal judge to dismiss a privacy class action claiming it collected personal data from people's cellphones after they switched off a ...
5 Pathophysiology. Toggle Pathophysiology subsection. 5.1 Neurological. ... has two peaks, one at 10–19 and another at 30–39 years, [4] and the prevalence is ...
The two New York Yankees fans who became infamous figures for interfering with Los Angeles Dodgers outfielder Mookie Betts in Game 4 of the 2024 World Series have been banned indefinitely from ...
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