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A phosphodiesterase-4 inhibitor, commonly referred to as a PDE4 inhibitor, is a drug used to block the degradative action of phosphodiesterase 4 (PDE4) on cyclic adenosine monophosphate (cAMP). It is a member of the larger family of PDE inhibitors. The PDE4 family of enzymes are the most prevalent PDE in immune cells. They are predominantly ...
1.1 cGMP phosphodiesterase inhibitors. 2 See also. 3 Sources. ... Download QR code; Print/export Download as PDF; Printable version; In other projects Wikidata item ...
It acts as a selective, long-acting inhibitor of the enzyme phosphodiesterase-4 (PDE-4). [10] It has anti-inflammatory effects. [10] [11] [12] It was approved for medical use in the European Union in 2010, [7] in the United States in 2011, [4] and in Canada in 2017. [1] It is available as a generic medication. [13]
It showed reasonable efficacy for treating COPD, but side effects were problematic and it is unclear whether cilomilast will be marketed, or merely used in the development of newer drugs. [ 3 ] [ 4 ] Cilomilast is a second-generation PDE4 inhibitor with anti-inflammatory effects that target bronchoconstriction , mucus hypersecretion, and airway ...
Phosphodiesterase-5. A phosphodiesterase inhibitor is a drug that blocks one or more of the five subtypes of the enzyme phosphodiesterase (PDE), thereby preventing the inactivation of the intracellular second messengers, cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) by the respective PDE subtype(s).
The potential for selective phosphodiesterase inhibitors to be used as therapeutic agents was predicted in the 1970s by Weiss and coworkers. [5] This prediction has now come to pass in a variety of fields (e.g. sildenafil as a PDE5 inhibitor and Rolipram as a PDE4 inhibitor).
Rolipram continues to be used in research as a well-characterized PDE4 inhibitor. [ 3 ] : 669 It has been used in studies to understand whether PDE4 inhibition could be useful in autoimmune diseases , [ 5 ] Alzheimer's disease, [ 6 ] cognitive enhancement, [ 7 ] spinal cord injury, [ 8 ] and respiratory diseases like asthma and COPD .
Download QR code; Print/export Download as PDF; ... PDE4 inhibitors (23 P) PDE5 inhibitors (23 P) PDE7 inhibitors (1 P) PDE9 inhibitors (3 P) PDE10 inhibitors (2 P)