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An isotope-coded affinity tag (ICAT) is an in-vitro isotopic labeling method used for quantitative proteomics by mass spectrometry that uses chemical labeling reagents. [1] [2] [3] These chemical probes consist of three elements: a reactive group for labeling an amino acid side chain (e.g., iodoacetamide to modify cysteine residues), an isotopically coded linker, and a tag (e.g., biotin) for ...
The 2018 issue has a list of about 180 such databases and updates to previously described databases. [2] Omics Discovery Index can be used to browse and search several biological databases. Furthermore, the NIAID Data Ecosystem Discovery Portal developed by the National Institute of Allergy and Infectious Diseases (NIAID) enables searching ...
The Pediatric Risk of Mortality (PRISM) score was developed from the Physiologic Stability Index (PSI) [1] to reduce the number of physiologic variables required for pediatric intensive-care unit (PICU) mortality risk assessment, from 34 (in the PSI) to 14, [2] and to obtain an objective weighting of the remaining variables.
MIRIAM (Minimum Information Required In The Annotation of Models [1]) is a community-level effort to standardize the annotation and curation processes of quantitative models of biological systems. [2] It consists of a set of guidelines suitable for use with any structured format, allowing different groups to collaborate and share resulting models.
Pedigree chart Used to show the occurrence of phenotypes of a particular gene or organism and its ancestors from one generation to the next, [ 7 ] [ 8 ] [ 9 ] most commonly humans , show dogs , [ 10 ] and race horses
Relational database concepts of computer science and Information retrieval concepts of digital libraries are important for understanding biological databases. Biological database design, development, and long-term management is a core area of the discipline of bioinformatics. [3]
The PICU most commonly referred to as first is the Children’s Hospital of Philadelphia in 1967 by John Downes. [5] The PICU at Lurie Children's Hospital was also established in 1967, the same year as the unit at the Children's Hospital of Philadelphia. The establishment of these early units eventually led to hundreds of PICUs being developed ...
There are models with both diffusion and reaction. [2] Unfortunately, a single FRAP curve may provide insufficient evidence to reliably and uniquely fit (possibly noisy) experimental data. Sadegh Zadeh et al. [ 16 ] have shown that FRAP curves can be fitted by different pairs of values of the diffusion constant and the on-rate constant, or, in ...