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Tuberculosis of the lungs may also occur via infection from the blood stream. This is known as a Simon focus and is typically found in the top of the lung. [91] This hematogenous transmission can also spread infection to more distant sites, such as peripheral lymph nodes, the kidneys, the brain, and the bones.
Treatment of active TB disease is typically a combination of antibiotics, which results in patients being non-infectious to others usually within a few weeks. Until that point, though, patients can spread TB to others and it’s typically adults with reactivated TB that are the most infectious.
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Miliary tuberculosis is a form of tuberculosis that is characterized by a wide dissemination into the human body and by the tiny size of the lesions (1–5 mm). Its name comes from a distinctive pattern seen on a chest radiograph of many tiny spots distributed throughout the lung fields with the appearance similar to millet seeds—thus the term "miliary" tuberculosis.
M. tuberculosis can also grow on the lipid cholesterol as a sole source of carbon, and genes involved in the cholesterol use pathway(s) have been validated as important during various stages of the infection lifecycle of M. tuberculosis, especially during the chronic phase of infection when other nutrients are likely not available. [47]
Tuberculous meningitis, also known as TB meningitis or tubercular meningitis, is a specific type of bacterial meningitis caused by the Mycobacterium tuberculosis infection of the meninges—the system of membranes which envelop the central nervous system.
Numerous rod shaped tuberculosis bacilli can be seen. There are several ways by which tuberculosis can infect the abdomen. The tubercle bacteria many enter the abdomen via the consumption of infected milk. Those with existing pulmonary tuberculosis can have abdominal tuberculosis through the ingestion of infected sputum. [2]
In these areas, tuberculomas can account for between 30%-50% of intracranial masses. [22] [3] India and parts of Asia are two areas where tuberculomas have been noted to be particularly prevalent. [20] They occur most often as solitary, infratentorial lesions in young children. [3] In contrast, lesions are most often supratentorial in adults. [3]