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It is desirous for the value of LD 50 to be as large as possible, to decrease risk of lethal effects and increase the therapeutic window. In the above formula, TI safety increases as the difference between LD 50 and ED 50 increases—hence, a higher safety-based therapeutic index indicates a larger therapeutic window, and vice versa.
The near-infrared (NIR) window (also known as optical window or therapeutic window) defines the range of wavelengths from 650 to 1350 nanometre (nm) where light has its maximum depth of penetration in tissue. [1] Within the NIR window, scattering is the most dominant light-tissue interaction, and therefore the propagating light becomes diffused ...
The therapeutic window is the amount of a medication between the amount that gives an effect (effective dose) and the amount that gives more adverse effects than desired effects. For instance, medication with a small pharmaceutical window must be administered with care and control, e.g. by frequently measuring blood concentration of the drug ...
In pharmacology, an effective dose (ED) or effective concentration (EC) is the dose or concentration of a drug that produces a biological response. [1] [2] The term "effective dose" is used when measurements are taken in vivo, while "effective concentration" is used when the measurements are taken in vitro.
The therapeutic window article has a huge amount of overlap and is a poor quality stub. They should be merged and if there is any difference between the two it should be detailed here. Testem 21:28, 5 January 2015 (UTC) Article merged: See old talk-page here.
The protective index is similar to the therapeutic index, but concerns toxicity (TD 50) rather than lethality (LD 50); thus, the protective index is a smaller ratio. Toxicity can take many forms, as drugs typically have multiple side effects of varying severity, so a specific criterion of toxicity must be specified for the protective index to ...
This is especially useful in the area of psychiatric pharmacy because a lot of drugs used to treat psychiatric illnesses (for example, lithium citrate and clozapine) have a narrow therapeutic window. There is a lot of potential for severe adverse reactions when using certain psychiatric medications, making therapeutic drug monitoring a useful ...
It is widely used in clinical trials for newer medicines to investigate therapeutic effectiveness and safety. C trough is slightly different from C min, the minimum concentration during the time interval between administration of two doses. [1] [2]