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Cefpodoxime is an oral, third-generation cephalosporin antibiotic available in various generic preparations. It is active against both Gram-positive and Gram-negative organisms with notable exceptions including Pseudomonas aeruginosa , Enterococcus , and Bacteroides fragilis .
In the dog, the half-life of cefovecin is 5.5 days, and in the cat, it is 6.9 days. [7] In birds and reptiles, the half-life is only a few hours, much shorter than in dogs and cats. [ 8 ] In cats, 99% of cefovecin is bound to proteins in the blood plasma .
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/ ˌ s ɛ f ə l ə ˈ s p ɔːr ɪ n, ˌ k ɛ-,-l oʊ-/ [1] [2]) are a class of β-lactam antibiotics originally derived from the fungus Acremonium, which was previously known as Cephalosporium. [3] Together with cephamycins, they constitute a subgroup of β-lactam antibiotics called cephems. Cephalosporins were discovered in 1945, and first ...
carprofen – COX-2 selective NSAID used to relieve pain and inflammation in dogs and cats; cefpodoxime – antibiotic; cephalexin – antibiotic, particularly useful for susceptible Staphylococcus infections; ciprofloxacin – antibiotic of quinolone group
Narrow-spectrum antibiotics have low propensity to induce bacterial resistance and are less likely to disrupt the microbiome (normal microflora). [3] On the other hand, indiscriminate use of broad-spectrum antibiotics may not only induce the development of bacterial resistance and promote the emergency of multidrug-resistant organisms, but also cause off-target effects due to dysbiosis.