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The dysregulation of T h 17 and switch to Th17 pathogenic phenotype cells have been associated with autoimmune disorders and inflammation. In the case of autoimmune disorders, T h 17 cell over activation can cause an inappropriate amount of inflammation, like in the case of rheumatoid arthritis.
Th17 cells gain the pathogenic phenotype by induction with pro-inflammatory cytokines IL-1β, IL-6 and IL-23 during their maturation. On the other hand, regulation of the Th17 immune response by TGFβ1 and IL-10 is known to inhibit Th17 pathogenicity.
Originally, Th17 was identified in 1993 by Rouvier et al. who isolated IL17A transcript from a rodent T-cell hybridoma. [3] The protein encoded by IL17A is a founding member of IL-17 family (see below). IL17A protein exhibits a high homology with a viral IL-17-like protein encoded in the genome of T-lymphotropic rhadinovirus Herpesvirus saimiri ...
T h cells contain and release cytokines to aid other immune cells. Cytokines are small protein mediators that alter the behavior of target cells that express receptors for those cytokines. These cells help polarize the immune response depending on the nature of the immunological insult (for example; virus vs. extracellular bacterium vs ...
6361 20295 Ensembl ENSG00000102970 ENSMUSG00000031780 UniProt Q92583 n/a RefSeq (mRNA) NM_002987 NM_011332 RefSeq (protein) NP_002978 n/a Location (UCSC) Chr 16: 57.4 – 57.42 Mb Chr 8: 95.54 – 95.54 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse CCL17 is a powerful chemokine produced in the thymus and by antigen-presenting cells like dendritic cells, macrophages, and monocytes ...
Cellular immunity protects the body through: T-cell mediated immunity or T-cell immunity: activating antigen-specific cytotoxic T cells that are able to induce apoptosis in body cells displaying epitopes of foreign antigen on their surface, such as virus-infected cells, cells with intracellular bacteria, and cancer cells displaying tumor antigens;
Type IV hypersensitivity, in the Gell and Coombs classification of allergic reactions, often called delayed-type hypersensitivity, is a type of hypersensitivity reaction that can take a day or more to develop. [1] Unlike the other types, it is not humoral (not antibody-mediated) but rather is a type of cell-mediated response.
Similar functions have IL-1 to Th17 cells and IL-18 to Th1 lymphocytes. IL-1 combined with some STAT3 activators, such as IL-6, IL-21 or IL-23, which are important for Th17 lymphocytes differentiation, have similar positive feedback in Th17 cells just like IL-33 and STAT5 activators have in Th2 cells.