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The key cellular components of the neuroimmune system are glial cells, including astrocytes, microglia, and oligodendrocytes. [1] [2] [5] Unlike other hematopoietic cells of the peripheral immune system, mast cells naturally occur in the brain where they mediate interactions between gut microbes, the immune system, and the central nervous system as part of the microbiota–gut–brain axis.
Brain cells make up the functional tissue of the brain. The rest of the brain tissue is the structural stroma that includes connective tissue such as the meninges , blood vessels , and ducts. The two main types of cells in the brain are neurons , also known as nerve cells, and glial cells , also known as neuroglia. [ 1 ]
Endogenous regeneration in the brain is the ability of cells to engage in the repair and regeneration process. While the brain has a limited capacity for regeneration, endogenous neural stem cells, as well as numerous pro-regenerative molecules, can participate in replacing and repairing damaged or diseased neurons and glial cells.
In general, neuroglial cells are smaller than neurons. There are approximately 85 billion glia cells in the human brain, [8] about the same number as neurons. [8] Glial cells make up about half the total volume of the brain and spinal cord. [27] The glia to neuron-ratio varies from one part of the brain to another.
The Neuronal cell cycle represents the life cycle of the biological cell, its creation, reproduction and eventual death. The process by which cells divide into two daughter cells is called mitosis . Once these cells are formed they enter G1, the phase in which many of the proteins needed to replicate DNA are made.
A sustentacular cell is a type of cell primarily associated with structural support, they can be found in various tissues. [ 1 ] Sustentacular cells of the olfactory epithelium (also called supporting cells or Sertoli cells ) have been shown to be involved in the phagocytosis of dead neurons, [ 2 ] odorant transformation [ 3 ] and xenobiotic ...
Betz cells are not the sole source of direct connections to those neurons because most of the direct corticomotorneuronal cells are medium or small neurons. [3] While Betz cells have one apical dendrite typical of pyramidal neurons, they have more primary dendritic shafts, which can branch out at almost any point from the soma (cell body). [4]
[1] [2] The brain is an extremely complex system of heterogeneous tissues and consists of a diverse array of neurons and glial cells. This complexity has made studying the brain and understanding how it works a difficult task in neuroscience, especially when it comes to neurodevelopmental and neurodegenerative diseases.