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The rebound effect, or pharmaceutical rebound phenomenon, is the emergence or re-emergence of symptoms that were either absent or controlled while taking a medication, but appear when that same medication is discontinued, or reduced in dosage.
The medications included prednisone, and methylprednisolone, plus albuterol, beclomethasone, dexamethasone, cromolyn, salmeterol and clarithromycin. Within days of beginning the glucocorticoid treatment, however, the patient began to show symptoms that included major depression, irritability, muscle weakness, and hallucinations ("stars" or ...
The neuropsychiatric effects are partly mediated by sensitization of the body to the actions of adrenaline. Therapeutically, the bulk of corticosteroid dose is given in the morning to mimic the body's diurnal rhythm; if given at night, the feeling of being energized will interfere with sleep. An extensive review is provided by Flores and Gumina ...
Another issue: Taking zinc supplements for long periods of time at high doses can deplete your body of copper, which may lead to neurological problems such as body weakness or numbness, according ...
Topical steroid withdrawal, also known as red burning skin and steroid dermatitis, has been reported in people who apply topical steroids for 2 weeks or longer and then discontinue use. [ 4 ] [ 5 ] [ 2 ] [ 1 ] Symptoms affect the skin and include redness, a burning sensation, and itchiness, [ 2 ] which may then be followed by peeling.
Adrenal insufficiency (if used for long time and stopped suddenly without a taper) Muscle and tendon breakdown (proteolysis), weakness, reduced muscle mass and repair [51] [31] Expansion of malar fat pads and dilation of small blood vessels in skin; Lipomatosis within the epidural space [52] Excitatory effect on central nervous system (euphoria ...
The mechanisms of sympathomimetic drugs can be direct-acting (direct interaction between drug and receptor), such as α-adrenergic agonists, β-adrenergic agonists, and dopaminergic agonists; or indirect-acting (interaction not between drug and receptor), such as MAOIs, COMT inhibitors, release stimulants, and reuptake inhibitors that increase the levels of endogenous catecholamines.
The low-calorie supplement contains 5 types of collagen (types I, II, III, V, and X), is fortified with added vitamins C, B6, and zinc, and includes tryptophan for 8g of complete protein per serving.