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In United States pharmaceutical regulatory practice, a Complete Response Letter (CRL), or more rarely, a 314.110 letter, is a regulatory action by the Food and Drug Administration in response to a New Drug Application, Amended New Drug Application or Biologics License Application, indicating that the application will not be approved in its present form. [1]
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In 1998 a landmark agreement for mass migration response was signed by Governor Chiles and the U.S. Immigration and Naturalization Commissioner. [4] On September 5, 2003, the State Emergency Response Team became the first state program in the nation to be fully accredited by the Emergency Management Accreditation Program (EMAP). [5]