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In molecular biology, protein aggregation is a phenomenon in which intrinsically-disordered or mis-folded proteins aggregate (i.e., accumulate and clump together) either intra- or extracellularly. [1] [2] Protein aggregates have been implicated in a wide variety of diseases known as amyloidoses, including ALS, Alzheimer's, Parkinson's and prion ...
Coacervate droplets dispersed in a dilute phase. Coacervate (/ k oʊ ə ˈ s ɜːr v ə t / or / k oʊ ˈ æ s ər v eɪ t /) is an aqueous phase rich in macromolecules such as synthetic polymers, proteins or nucleic acids.
Channel formation has been hypothesized to account for calcium dysregulation and mitochondrial dysfunction by allowing indiscriminate leakage of ions across cell membranes. [71] Studies have shown that amyloid deposition is associated with mitochondrial dysfunction and a resulting generation of reactive oxygen species (ROS), which can initiate ...
In biology the term 'condensation' is used much more broadly and can also refer to liquid–liquid phase separation to form colloidal emulsions or liquid crystals within cells, and liquid–solid phase separation to form gels, [1] sols, or suspensions within cells as well as liquid-to-solid phase transitions such as DNA condensation during ...
Schematic of sediment accumulation (aggradation) in a river channel. The sediment is brown. The river is flowing on bedrock in the upper image, but because sediment was deposited over time the riverbed has risen. This has caused the house to be buried in the lower image.
Bioaccumulation is the gradual accumulation of substances, such as pesticides or other chemicals, in an organism. [1] Bioaccumulation occurs when an organism absorbs a substance faster than it can be lost or eliminated by catabolism and excretion.
Therefore, a greater investment in growth and reproduction would result in reduced investment in DNA repair maintenance, leading to increased cellular damage, shortened telomeres, accumulation of mutations, compromised stem cells, and ultimately, senescence. Although many models, both animal and human, have appeared to support this theory ...
Alzheimer's disease (AD) has been identified as a proteopathy: a protein misfolding disease due to the accumulation of abnormally folded amyloid beta (Aβ) protein in the brain. [1] Amyloid beta is a short peptide that is an abnormal proteolytic byproduct of the transmembrane protein amyloid-beta precursor protein (APP), whose function is ...