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Acitretin is a metabolite of etretinate, which was used prior to the introduction of acitretin. Etretinate was discontinued because it had a narrow therapeutic index as well as a long elimination half-life (t 1/2 = 120 days), making dosing difficult. In contrast, acitretin's half-life is approximately 2 days.
Etretinate has been replaced by acitretin, the free acid (without the ethyl ester). While acitretin is less lipophilic and has a half-life of only 50 hours, it is partly metabolized to etretinate in the body, [ 2 ] so that it is still a long-acting teratogen and pregnancy is prohibited for two years after therapy.
A map of the 77 community areas, broken down by purported regions. While the areas have official use and definition, the color groupings are unofficial, and such "regions" may be defined differently, grouped differently, or not be used at all. The city of Chicago is divided into 77 community areas for statistical and planning purposes.
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Module:Location map/data/United States Chicago metropolitan area is a location map definition used to overlay markers and labels on an equirectangular projection map of Chicago metropolitan area. The markers are placed by latitude and longitude coordinates on the default map or a similar map image.
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The color of the sputum is determined by immune cells fighting an infection in the nasal area. [314] Vitamin C does not prevent or treat the common cold, although it may have a protective effect during intense cold-weather exercise. If taken daily, it may slightly reduce the duration and severity of colds, but it has no effect if taken after ...