Search results
Results From The WOW.Com Content Network
The dentate gyrus is part of the trisynaptic circuit, a neural circuit of the hippocampus, thought to contribute to the formation of new episodic memories, [3] [4] the spontaneous exploration of novel environments [4] and other functions. [5] The dentate gyrus has toothlike projections from which it is named. [6]
The dentate gyrus is composed of a similar series of strata: The polymorphic layer is the most superficial layer of the dentate gyrus and is often considered a separate subfield (as the hilus). This layer contains many interneurons, and the axons of the dentate granule cells pass through this stratum on the way to CA3.
The hippocampal subfields are four subfields CA1, CA2, CA3, and CA4 that make up the structure of the hippocampus.Regions described in the hippocampus are the head, body, and tail, and other hippocampal subfields include the dentate gyrus, the presubiculum, and the subiculum.
Typically, the hippocampal formation is said to included the dentate gyrus, the hippocampus, and the subiculum. [2] The presubiculum, parasubiculum, and the entorhinal cortex may also be included. [3] The hippocampal formation is thought to play a role in memory, spatial navigation and control of attention.
The dentate gyrus (DG) is the innermost section of the hippocampal formation. The dentate gyrus consists of three layers: molecular, granular, and polymorphic. Granule neurons, which are the most prominent type of DG cells, are mainly found in the granular layer.
In mice, the projection to CA1, and the subiculum all come primarily from EC layer III. [citation needed]According to Suh et al. (2011 Science 334:1415) the projection to CA3 and dentate gyrus in mice is primarily from layer II of entorhinal cortex, and forms a trisynaptic path with hippocampus (dentate gyrus to CA3 to CA1), distinguished from the direct (monosynaptic) perforant path from ...
Dentate granule cells. Loss of dentate gyrus neurons from the hippocampus results in spatial memory deficits. Therefore, dentate granule cells are thought to function in the formation of spatial memories [17] and of episodic memories. [18] Immature and mature dentate granule cells have distinct roles in memory function.
Structure and features of the neurogenic niche. Adapted from a paper by Ilias Kazanis, et al., 2008. The brain comprises many different types of neurons, but the SGZ generates only one type: granule cells—the primary excitatory neurons in the dentate gyrus (DG)--which are thought to contribute to cognitive functions such as memory and learning.