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Besides mammals, serotonin is found in all bilateral animals including worms and insects, [19] as well as in fungi and in plants. [20] Serotonin's presence in insect venoms and plant spines serves to cause pain, which is a side-effect of serotonin injection. [21] [22] Serotonin is produced by pathogenic amoebae, causing diarrhea in the human ...
Serotonin pathways are thought to modulate eating, both the amount as well as the motor processes associated with eating. The serotonergic projections into the hypothalamus are thought to be particularly relevant, and an increase in serotonergic signaling is thought to generally decrease food consumption (evidenced by fenfluramine , however ...
The serotonin transporter (SERT or 5-HTT) also known as the sodium-dependent serotonin transporter and solute carrier family 6 member 4 is a protein that in humans is encoded by the SLC6A4 gene. [5] SERT is a type of monoamine transporter protein that transports the neurotransmitter serotonin from the synaptic cleft back to the presynaptic ...
The 7 general serotonin receptor classes include a total of 14 known serotonin receptors. [9] The 15th receptor 5-HT 1P has been distinguished on the basis of functional and radioligand binding studies, its existence has never been definitely affirmed or refuted. [10] [11] The specific types have been characterized as follows: [12] [13] [14]
The MRN is involved in the serotonin pathway. [3] Serotonin (5-HT) is the chief neurotransmitter of the median raphe nucleus. [4] According to one study, it represents the main source of serotonin (5-hydroxytryptamine (5-HT)) in the brain. [3] Stimulation of the MRN significantly increases the amount of 5-HT present in the brain. [5]
Monoamine transporters are established targets for many pharmacological agents that affect brain function, including the psychostimulants cocaine and amphetamine. Cocaine and amphetamine employ different mechanisms that both result in an increase in extracellular monoamines by decreasing reuptake.
15550 Ensembl ENSG00000178394 ENSMUSG00000021721 UniProt P08908 Q64264 RefSeq (mRNA) NM_000524 NM_008308 RefSeq (protein) NP_000515 NP_032334 Location (UCSC) Chr 5: 63.96 – 63.96 Mb Chr 13: 105.58 – 105.58 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse The serotonin 1A receptor (or 5-HT 1A receptor) is a subtype of serotonin receptors, or 5-HT receptors, that binds serotonin ...
Cell group B9 is a group of cells located in the pontine tegmentum, ventral to serotonergic group B8. In the nonhuman primate they are found in the ventral part of the superior central nucleus and adjacent structures. [3] In the rodent they have a more lateral location within the medial lemniscus of the pons and dorsal and medial to it., [4] [5]