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Extrapyramidal symptoms including dyskinesias (acute & delayed) Dystonic reactions; Cogwheel rigidity; Emotional lability; Psychosis; Suicidal ideation; Ataxias; Transient difficulty with recall; Serotonin syndrome; Parkinsonism; Restless leg syndrome; Restlessness; Eye pain; Altered sense of smell; Photophobia; Pressure on eyes; Inner ear ...
Tremor; Respiratory depression; Epileptiform convulsions; Involuntary muscle contractions; Abnormal coordination; Syncope (fainting) Blurred vision; Dyspnoea (shortness of breath) Tinnitus (ringing in the ears) Migraine; Stevens–Johnson syndrome/toxic epidermal necrolysis (potentially fatal skin reactions) Motorial weakness; Creatinine ...
Symptoms may include tinnitus, [29] [125] psychosis, cognitive deficits, gastrointestinal complaints, insomnia, paraesthesia (tingling and numbness), pain (usually in limbs and extremities), muscle pain, weakness, tension, painful tremor, shaking attacks, jerks, dizziness and blepharospasm [20] and may occur even without a pre-existing history ...
Peripheral neuropathy may be classified according to the number and distribution of nerves affected (mononeuropathy, mononeuritis multiplex, or polyneuropathy), the type of nerve fiber predominantly affected (motor, sensory, autonomic), or the process affecting the nerves; e.g., inflammation (), compression (compression neuropathy), chemotherapy (chemotherapy-induced peripheral neuropathy).
They can cause neuropathy characterized by paresthesias, numbness, and pain in the hands and feet. Sensory and motor symptoms are commonly seen in patients treated with epothilone, which generally results in muscle weakness, while autonomic symptoms are rarely seen. The symptoms of this drug occur during treatment and tend to stop after completion.
Medications are used to reverse the symptoms of extrapyramidal side effects caused by antipsychotics or other drugs, by either directly or indirectly increasing dopaminergic neurotransmission. The treatment varies by the type of the EPS, but may involve anticholinergic agents such as procyclidine, benztropine, diphenhydramine, and trihexyphenidyl.
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