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Exchange of gases in the lung occurs by ventilation and perfusion. [1] Ventilation refers to the in-and-out movement of air of the lungs and perfusion is the circulation of blood in the pulmonary capillaries. [1] In mammals, physiological respiration involves respiratory cycles of inhaled and exhaled breaths.
This blood–air barrier is extremely thin (approximately 600 nm-2μm; in some places merely 200 nm) to allow sufficient oxygen diffusion, yet it is extremely strong. This strength comes from the type IV collagen in between the endothelial and epithelial cells. Damage can occur to this barrier at a pressure difference of around 40 millimetres ...
The equilibration of the partial pressures of the gases in the alveolar blood and the alveolar air occurs by diffusion. After exhaling, adult human lungs still contain 2.5–3 L of air, their functional residual capacity or FRC. On inhalation, only about 350 mL of new, warm, moistened atmospheric air is brought in and is well mixed with the FRC.
The lungs' interiors are open to the outside air and being elastic, therefore expand to fill the increased space, pleura fluid between double-layered pleura covering of lungs helps in reducing friction while lungs expand and contract. The inflow of air into the lungs occurs via the respiratory airways (Fig. 2).
Exchange of gases between the air in the lungs and the blood in the capillaries occurs across the walls of the alveolar ducts and alveoli. The alveolar ducts and alveoli consist primarily of simple squamous epithelium, which permits rapid diffusion of oxygen and carbon dioxide.
Diffusing capacity of the lung (D L) (also known as transfer factor) measures the transfer of gas from air in the lung, to the red blood cells in lung blood vessels. It is part of a comprehensive series of pulmonary function tests to determine the overall ability of the lung to transport gas into and out of the blood.
Therefore, oxygen has a diffusion rate in air 10,000 times greater than in water. [23] The use of sac-like lungs to remove oxygen from water would therefore not be efficient enough to sustain life. [23] Rather than using lungs, gaseous exchange takes place across the surface of highly vascularized gills.
Perfusion occurs during heart contraction when the oxygenated blood is pumped into the arteries. The arteries deliver the blood to the capillary bed of the tissues, where the oxygen is removed by diffusion. [7] Oxygen in the alveoli is diffused down the concentration gradient and transported into the blood through the pulmonary capillaries.