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The RALES trial [30] showed that the addition of spironolactone can improve mortality, particularly in severe cardiomyopathy (ejection fraction less than 25%.) The related medication eplerenone was shown in the EPHESUS trial [ 31 ] to have a similar effect, and it is specifically labelled for use in decompensated heart failure complicating ...
Given the selective decrease in rate without loss of contractility, ivabradine may prove efficacious for treatment of congestive heart failure with reduced ejection fraction. Ivabradine binds to HCN4 receptors (potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4), utilizing Y506, F509 and I510 residues.
Drug examples General indications Common side effects Cautions Special populations Digoxin [8]. Digitalis [8]. Digitoxin [8]. Heart failure with reduced ejection fraction [9]. Atrial Fibrillation (abnormal heart rhythm) [9]
Researchers also observed improvements in the left ventricle, including better ejection fraction and reverse remodeling. In terms of overall survival rates, the tricaprin group had 100% three-year ...
Soluble guanylate cyclase (sGC) stimulators are a class of drugs developed to treat heart failure, pulmonary hypertension, and other diseases. The first-in-class medication was riociguat, approved in 2013 for pulmonary hypertension.
This is known as heart failure with preserved ejection fraction (HFpEF). Congenital heart disease ... certain medications during pregnancy, such as statins ... immediate treatment to improve blood ...
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