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Griffith's experiment discovering the "transforming principle" in Streptococcus pneumoniae (pneumococcal) bacteria. Griffith's experiment, [1] performed by Frederick Griffith and reported in 1928, [2] was the first experiment suggesting that bacteria are capable of transferring genetic information through a process known as transformation.
Frederick Griffith (1877–1941) was a British bacteriologist whose focus was the epidemiology and pathology of bacterial pneumonia. In January 1928 he reported what is now known as Griffith's experiment , the first widely accepted demonstrations of bacterial transformation , whereby a bacterium distinctly changes its form and function .
In Griffith's experiment, mice are injected with dead bacteria of one strain and live bacteria of another, and develop an infection of the dead strain's type. 1928: Frederick Griffith discovers that hereditary material from dead bacteria can be incorporated into live bacteria.
January – Frederick Griffith reports the results of Griffith's experiment, indirectly proving the existence of DNA. [1] [2]September 28 – Scottish-born microbiologist Alexander Fleming, at St Mary's Hospital, London, accidentally rediscovers the antibiotic which he will call Penicillin, [3] [4] forgotten since Ernest Duchesne's original discovery in 1896.
Griffith's experiment, reported in 1928 by Frederick Griffith, [23] was the first experiment suggesting that bacteria are capable of transferring genetic information through a process known as transformation.
Transformation in bacteria was first demonstrated in 1928 by the British bacteriologist Frederick Griffith. [3] Griffith was interested in determining whether injections of heat-killed bacteria could be used to vaccinate mice against pneumonia.
Griffith's experiment, reported in 1928, [4] identified that some "transforming principle" in pneumococcal bacteria could transform them from one type to another. Griffith, a British medical officer, had spent years applying serological typing to cases of pneumonia, a frequently fatal disease in the early 20th century. He found that multiple ...
Griffith proved the existence of a "transforming principle", which Avery, MacLeod and McCarty later showed to be DNA. Various genetic discoveries have been essential in the development of genetic engineering. Genetic inheritance was first discovered by Gregor Mendel in 1865 following experiments crossing peas.