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Bubonic plague 15–100 million 25–60% of European population [5] 541–549 North Africa, Europe, and Western Asia 3 HIV/AIDS pandemic: HIV/AIDS: 44 million (as of 2025) [a] 1981–present [6] Worldwide 1 Black Death: Bubonic plague: 25–50 million 30–60% of European population [7] 1346–1353 Europe, Asia, and North Africa 5 COVID-19 pandemic
The COVID-19 vaccines are widely credited for their role in reducing the severity and death caused by COVID-19. [ 128 ] [ 129 ] As of March 2023, more than 5.5 billion people had received one or more doses [ 130 ] (11.8 billion in total) in over 197 countries.
Plague cases were massively reduced during the second half of the 20th century, but outbreaks still occurred, especially in developing countries. Between 1954 and 1997, human plague was reported in 38 countries, making the disease a re-emerging threat to human health. [ 65 ]
Colorado health officials have confirmed a human case of the plague, the rare bacterial infection infamously known for killing tens of millions in 14th century Europe. Today, it's easily treated ...
T he plague sounds like something out of a history book. But the disease—nicknamed the “Black Death” or “Great Pestilence”—that killed more than 25 million people, about a third of ...
The bubonic plague is a devastating disease that kills your body from the inside out. 75 million people, including over half of Europe's population, were affected by the disease in the 14th century.
Human infectious diseases may be characterized by their case fatality rate (CFR), the proportion of people diagnosed with a disease who die from it (cf. mortality rate).It should not be confused with the infection fatality rate (IFR), the estimated proportion of people infected by a disease-causing agent, including asymptomatic and undiagnosed infections, who die from the disease.
Though COVID-19 is not as dangerous as it once was, it is still deadly for some, including young children, the elderly, and the immunocompromised, and it carries the risk of long COVID.