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  2. Simvastatin - Wikipedia

    en.wikipedia.org/wiki/Simvastatin

    Simvastatin is an effective serum lipid-lowering drug that can decrease low density lipoprotein (LDL) levels by up to 50%. [citation needed] Simvastatin had been shown to interact with lipid-lowering transcription factor PPAR-alpha [36] and that interaction might control the neurotrophic action of the drug.

  3. Dyslipidemia: What It Is & How to Treat It - AOL

    www.aol.com/dyslipidemia-treat-105700223.html

    Statin therapy isn’t for everyone, though. Your healthcare provider can walk you through the pros, cons, and side effects of these medications and help you find the best treatment for you. Other ...

  4. Heart Protection Study - Wikipedia

    en.wikipedia.org/wiki/Heart_Protection_Study

    Initial results [4] were published in 2002, which indicated that vitamins made little difference in modifying cardiovascular risk, but that simvastatin could significantly reduce the risk of cardiovascular events. Further publications, from 2003 and 2004, were concerned with the efficacy of simvastatin in diabetes patients [5] and preventing ...

  5. Rosuvastatin - Wikipedia

    en.wikipedia.org/wiki/Rosuvastatin

    The effects of rosuvastatin on low-density lipoprotein (LDL) cholesterol are dose-related. Higher doses were more efficacious in improving the lipid profile of patients with hypercholesterolemia than milligram-equivalent doses of atorvastatin and milligram-equivalent or higher doses of simvastatin and pravastatin.

  6. Fewer people may need statins to prevent heart disease, new ...

    www.aol.com/news/fewer-people-may-statins...

    Statins, such as Lipitor, Crestor and Zocor, are widely used to protect against high levels of LDL cholesterol, one of the causes of cardiovascular disease. Doctors prescribe the daily pills based ...

  7. Scandinavian Simvastatin Survival Study - Wikipedia

    en.wikipedia.org/wiki/Scandinavian_Simvastatin...

    The Scandinavian Simvastatin Survival Study (also known as the 4S study), was a multicentre, randomized, double-blind, placebo-controlled clinical trial, which provided the initial data that supported the use of the cholesterol-lowering drug, simvastatin, in people with a moderately raised cholesterol and coronary heart disease (CHD); that is people who had previously had a heart attack or angina.

  8. The pros and cons of Medicare Advantage plans - AOL

    www.aol.com/finance/pros-cons-medicare-advantage...

    Here’s a rundown of the pros and cons of Medicare Advantage plans. Pros of Medicare Advantage plans Potentially lower out-of-pocket costs than Original Medicare. For example, ...

  9. Sitagliptin/simvastatin - Wikipedia

    en.wikipedia.org/wiki/Sitagliptin/simvastatin

    Simvastatin: No tumorigenic effect was seen in a 72-week carcinogenicity study using mice at the low dose levels. However, at the higher dose levels (eight and 16 times the human dose equivalent), liver carcinomas and adenomas, lung adenomas, and adenomas of the Harderian gland occurred. No mutagenic effects were seen in assays.