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Major basic protein, eosinophil peroxidase, and eosinophil cationic protein are toxic to many tissues. [21] Eosinophil cationic protein and eosinophil-derived neurotoxin are ribonucleases with antiviral activity. [24] Major basic protein induces mast cell and basophil degranulation, and is implicated in peripheral nerve remodelling.
Eosinophilia is a condition in which the eosinophil count in the peripheral ... platelet activating factor), and toxic proteins (e.g. metalloproteinases, major ...
The symptoms of DRESS syndrome usually begin 2 to 6 weeks but uncommonly up to 8–16 weeks after exposure to an offending drug. Symptoms generally include fever, an often itchy rash which may be morbilliform or consist mainly of macules or plaques, facial edema (i.e. swelling, which is a hallmark of the disease), enlarged and sometimes painful lymph nodes, and other symptoms due to ...
More than 1,500/mL of blood eosinophilia for more than six months in a row, along with hypereosinophilic disease signs and symptoms. [23] Lack of an underlying cause for hypereosinophilia after a full diagnostic assessment. [23] Organ dysfunction or damage as a result of eosinophils' toxic contents being released locally. [23]
PRG2 is a 117-residue protein that predominates in eosinophil granules. It is a potent enzyme against helminths and is toxic towards bacteria and mammalian cells in vitro. The eosinophil major basic protein also causes the release of histamine from mast cells and basophils, and activates neutrophils and alveolar macrophages.
Eosinophil cationic protein (ECP) also known as ribonuclease 3 is a basic protein located in the eosinophil primary matrix. [4] In humans, the eosinophil cationic protein is encoded by the RNASE3 gene. [5] ECP is released during degranulation of eosinophils. This protein is related to inflammation and asthma because in these cases, there are ...
Antibody-dependent cellular cytotoxicity. Antibody-dependent cellular cytotoxicity (ADCC), also referred to as antibody-dependent cell-mediated cytotoxicity, is a mechanism of cell-mediated immune defense whereby an effector cell of the immune system kills a target cell, whose membrane-surface antigens have been bound by specific antibodies. [1]
Eosin Y Eosin B. Eosin is the name of several fluorescent acidic compounds which bind to and form salts with basic, or eosinophilic, compounds like proteins containing amino acid residues such as arginine and lysine, and stains them dark red or pink as a result of the actions of bromine on eosin.