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Salivary gland hypofunction has been defined as any objectively demonstrable reduction in whole and/or individual gland flow rates. [6] An unstimulated whole saliva flow rate in a normal person is 0.3–0.4 ml per minute, [7] and below 0.1 ml per minute is significantly abnormal.
An unstimulated salivary flow rate of 0.1 to 0.2 ml/min and a stimulated flow rate of 0.7 ml/min or less is considered to be abnormally low flow rates indicative of salivary gland hypofunction. [61] Unstimulated saliva production reduces by 40 to 70% between the age of 20 and 80 years, but stimulated saliva production is not affected. [62]
Buffering: In general, the higher the saliva flow rate, the faster the clearance and the higher the buffer capacity, hence better protection from dental caries. Therefore, people with a slower rate of saliva secretion, combined with a low buffer capacity, have lessened salivary protection against microbes. [25]
Salivary gland dysfunction affects the flow, amount, or quality of saliva produced. A reduced salivation is termed hyposalivation . Hyposalivation often results in a dry mouth condition called xerostomia , and this can cause tooth decay due to the loss of the protective properties of saliva.
The paired submandibular glands (historically known as submaxillary glands) are major salivary glands located beneath the floor of the mouth.In adult humans, they each weigh about 15 grams and contribute some 60–67% of unstimulated saliva secretion; on stimulation their contribution decreases in proportion as parotid gland secretion rises to 50%. [1]
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